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KMID : 0370219970410020203
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Yakhak Hoeji
1997 Volume.41 No. 2 p.203 ~ p.211
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Subacute Transdermal Toxicity Study of Syndella gel, Topical Drug Containing Deproteinised Dialysate of Calf’’s Blood and Micronomicin sulfate, in Rats
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남석우/Nam SW
성대석/유세근/장만식/최완수/정영국/김규봉/한정환/홍성렬/이향우/Sung DS/Yoo SK/Chang MS/Choi WS/Chung YK/Kim KB/Han JW/Hong SY/Lee HW
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Abstract
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This study was conducted to investigate the subacute transdermal toxicity of Syndella gel, a new topical drug containing deproteinized dialysate of calf’’s blood and micronomicin sulfate in Sprague-Dawley rats. Three doses (1.97, 3.94, 7.88 g/kg) of Syndella gel was daily treated transdermally to male and female rats for 30 days. No death was occurred in either control or treated rats. No significant toxic clinical signs and body weight change were not observed at any doses in the male or female rats treated. There were no significant alterations in hematologic and biochemical parameters in both sexes, however slight increase of potassium concentration was observed in 3.94g/kg and 7.88 g/kg female groups. No significant necrotic changes were not observed in examined organs. This study showed that up to 7.88g/kg Syndella gel did not induce subacute transdermal toxicity.
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KEYWORD
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